I have some experience with self-defense courses
although I have not taught it in a while but FYI:
FIRST, self-defense is a very different animal from martial arts. I've known rank beginners who would be a bear in a fight and very high ranking martial artists who could not fight their way out of a wet paper bag. I love martial arts... But when we're discussing women's self-defense in general, and the self defense for an escort, martial arts has little relevance unless you're willing to devote YEARS to its practice. And even then, you need to find the right instructor.
SECOND, as has been stated earlier in this post, the best self defense move you can make is one that keeps you from entering a bad situation. The first thing that a self-defense course should teach it to be AWARE, trust your instincts, and don't enter a potentially dangerous situation. Just as you should not walk into a dark alleyway alone at night, you should not enter a hotel room if you don't feel comfortable with the person in the room. I'd recommend reading "Gift of Fear" by Gavin de Becker as a good introduction to trusting your instincts.
THIRD, despite the above, if you find yourself in a hotel room with someone who wishes you harm, this is where the second principle that a competent self defense class should teach you comes in: How to hit. Not only in a mechanical sense but the biggest problem with civilized people in general and women in particular is that they have a conceptual problem with hitting others. We're indoctrinated from birth to "be nice." But nice doesn't help when you're under attack. You should how to hit and you should learn that it's okay to hit others when necessary. It sounds simple but you'd be amazed at how many nice people there are in the world. It's about ATTITUDE.
FOURTH, Charles Bronson and other actors aside, do not rely on pain to incapacitate. You want to attack motor functions and disable your attacker to the point where you can escape. Pain is not always reliable to incapacitate your attacker's ability to continue his threat (especially in a small room). But on a positive note, any strike or bar that is likely to disable is almost guaranteed to be painful, as well. But if you rely on pain alone, you're double damned because i) your attacker may have an abnormally high pain threshold due to drugs or by nature; and ii) you have a tendency to not complete the strike if causing pain is your objective -- e.g., if you're poking someone's eyes out and your intention is to take their sight away so you can escape, you will gouge. But if you're intent is to cause pain, you are likely to stop your attack when you've caused the opponent pain without impairing their sight, and therefore, their ability to continue the attack. (over simplified example but unfortunately true in my experience).
FIFTH, I generally heartily endorse OC (pepper) or mace. However, in a small enclosed space, you will likely get some splashback or residual impact from your spray. And while it's unlikely that your attacker will have had substantial exposure to pepper spray, it is possible to build a tolerance for it. So, my suggestion would be to be judicious in its use: i)use it and immediately RUN, do not rely on the spray alone to incapacitate - if you need to get dressed, etc., which I do NOT recommend, hit him in a soft spot with something big and heavy first; ii) spray yourself at least once if you're going to be carrying it -- you NEED to know what it feels like because you will be at least partially exposed to it if you use it in a small enclosed space like a hotel room -- you need to be familar with it so that *you* can function.
SIXTH, when all else fails, remember that HE is trying to take something from YOU that you VALUE VERY, VERY MUCH. Get pissed off, get resolved to do whatever is necessary to escape and if at all possible, hit him with something that's big and heavy, preferably when he's not looking. And you know what, if you don't want to be raped, fucking bite his tongue or dick off when he sticks it in your mouth. And you need to be VERY, VERY pissed off to do this.
Remember: You Are Not A Victim.
CAVEAT: as far as use of guns, knives, pepper, etc., is concerned, take it from my personal experience that under great emotional stress (like when you're being attacked), your fine motor functions WILL deteriorate and you WILL get tunnel vision. That's why we train. Whatever weapon you carry, don't just stick it in your purse, TRAIN with it to the point where you're so familiar with it that you can use it safely under real life threat.
