Especialy if you fly direct from Lima which is at sea level, the shock on your cardio system will be brutal, like walking a few meters and finding yourself out of breath.
I did the trip a long time ago but travelling on roads. I had plenty of time ahead of me( I spent a few months there), so I could slowly acclimate to the progressive rise in altitude.
Even then, I used coca leaves (as well as the white stuff but for a different reason

),to ease things up, Urquell’s recomendation to use coca candies instead is a great idea, since the effects might kick in quicker and sugar is also great to fight "soroche ".
This happened some 40 years ago, I was young and definately not there to monger. I consider myself very lucky, in those years, you could climb and visit Machu Picchu on your own and didnt have to book a tour or a guide, although those already exist at the time.
We took off from Agua Caliente and hike our way to the top at 4:30 in the morning to get to see the sun slowly revealing the mystic ancient city under our eyes. One of the most intense moment in my Life! Enjoy your trip!