Coronavirus

[EagerBeaver]

Pepcid Being Used to Treat Covid 19 in NYC Hospitals

The strategy of trying whatever is reasonable that might possibly work seems to be what is being followed in New York City:

https://www.cnn.com/2020/04/27/health/famotidine-coronavirus-northwell-trial/index.html

 

[hungry101]

I don't know Capt'n. I read the article and it sounds compelling but how does he vote in elections? What does Alexander Orcasio Cortez think? "Like! Like!"

Thanks for the great post. Staying on this same path is insane! In my town of 80 thousand, I have inside information from staff. We have had two dead who were both sick people already and there are three others hospitalized and the hospital stands half empty. This is insane!!!

 

[EagerBeaver]

Experts Say Americans Venturing Out Due to "Quarantine Fatigue"

"Quarantine fatigue" has started according to the experts:

https://www.google.com/amp/s/www.wa...a-a3eb-e9fc93160703_story.html?outputType=amp

I think part of it is also a sense that restrictions are being loosened as the curve begins to flatten. At this point only time will tell whether the trend has any consequences.

 

[Doc Holliday]

Quarantine fatigue. My ass!!!

Fatigued from being quarantined for how long? A month or so??

Remember: Anne Frank remained locked up in a small attic for nearly 2 years. Two years!!! She didn't complain. She spent the time writing a diary. The worse part of course is that the fucking Nazis still got her & murdered her!

 

[The Nature Boy]

They were showing pics of Newport Beach on BBC, gotta admit I was Jelly like Kelly. Wonder how warm water is in SoCal right now?

 

[hungry101]

I meant to reply...don’t know what happened...Anne Frank knew that the Nazis would kill her. About 90 % sure.
For this, I’m starting to think, for what purpose?

 

[bignasty]

For those advocating for an indefinite lockdown to fight the Covid-2 virus, know this: Of all previous viruses from the Coronavirus family there has never been a vaccine found. Even the common cold, which is a coronavirus, has been around for at least 200 years. HIV has been around now for at least 40 years and still infects over 1 million per year globally. Guess what - no vaccine. Luckily, we have powerful antivirals which help those with HIV live with the virus. The effectiveness of the seasonal "flu" vaccine varies from year to year, because the virus is constantly changing. A few years ago it was as low as 35%. WTF. There are many deadly viruses for which no vaccines have been found. For those who like DAO, close your eyes - 400,000 people worldwide die each year from liver cancer and other illnesses caused by Hep-C. Over 70 million people worldwide live with Hep-C.
Ann Frank had family and friends to commiserate with and bring food to her during her lockdown in her safe space. Many of us do not.
If the Canadian lockdown continues through the Summer months I predict there will be riots in the streets.

 

[The Nature Boy]

Lol, oh BigB, ur so silly. Who is advocating an indefinite lockdown? Who, come out, come out where ever you are.....

you need to hit the snooze luv

 

[CLOUD 500]

A description of things in Wuhan after reopening in a post Covid world. Might be a preview of how things will be in the western hemisphere. Things looks very bleak and gloomy -> https://www.bloomberg.com/news/feat...and-constant-anxiety?utm_source=pocket-newtab

 

[OnJustALark]

For those advocating for an indefinite lockdown to fight the Covid-2 virus, know this: ....

Well aid ... and there HAVE been SEVERAL on here "suggesting" at lockdown trough end of year - insanity.

That link to Wuhan info .... might "fly" in Canada but too many conservatives in US who will not allow every day liberties to be stripped over what has amount to as a really bad flu .... facts are facts.

 

[The Nature Boy]

Larry, come on now, who? who has suggested this?

 

[Rinzler]

what has amount to as a really bad flu .... facts are facts.

it's not a bad flu. it's far worse

stop trolling

 

[Rinzler]

Scott W. Atlas, MD, is the David and Joan Traitel Senior Fellow at Stanford University’s Hoover Institution and a former chief of neuroradiology at Stanford Medical Center.

rather than the hilarious "hypotheses" of a radiologist with no experience in epidemiology or infectious diseases, who writes a hit piece on behalf of the libertarian think thank he works for. here's what good scientific guidance looks like from experts on the subject:

What policy makers need to know about COVID-19 protective immunity

Daniel M Altmann Affiliations: Department of Immunology and Inflammation, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
Daniel C Douek Affiliations: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Rosemary J Boyton Affiliations: Department of Infectious Diseases, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK, Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, UK

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30985-5/fulltext#

Published:April 27, 2020

Current discussion, for example, addresses the notion that scaled up antibody testing will determine who is immune, thus giving an indication of the extent of herd immunity and confirming who could re-enter the workforce. There are questions to be addressed about the accuracy of tests and practicalities of implementation of laboratory-based versus home-use assays.5 For any country contemplating these issues, another crucial question is how solid is the assumption that antibodies to SARS-CoV-2 spike protein equate to functional protection? Furthermore, if presence of these antibodies is protective, how can it be decided what proportion of the population requires these antibodies to mitigate subsequent waves of cases of COVID-19?

Any discussions should be informed by consideration of correlates of protection. Initially proposed by Stanley Plotkin,6, 7 this concept rests on the notion of empirically defined, quantifiable immune parameters that determine the attainment of protection against a given pathogen. Caution is needed because total measurable antibody is not precisely the same as protective, virus-neutralising antibody. Furthermore, studies in COVID-19 show that 10–20% of symptomatically infected people have little or no detectable antibody.8 In some cases of COVID-19, low virus-binding antibody titres might correlate with lethal or near-lethal infection, or with having had a mild infection with little antigenic stimulation. Importantly, scientists must not only identify correlates of protection but also have a robust understanding of the correlates of progression to severe COVID-19, since knowledge of the latter will inform the former.

The route to certainty on the degree and nature of the immunity required for protection will require evidence from formal proofs using approaches such as titrated transfers of antibodies and T lymphocytes to define protection in non-human primate models, as used, for example, in studies of Ebola virus.9

A study of survivors of SARS showed that about 90% had functional, virus-neutralising antibodies and around 50% had strong T-lymphocyte responses.10 These observations bolster confidence in a simple view that most survivors of severe COVID-19 would be expected to have protective antibodies. A caveat is that most studies, either of SARS survivors or of COVID-19 patients, have focused on people who were hospitalised and had severe, symptomatic disease. Similar data are urgently needed for individuals with SARS-CoV-2 infection who have not been hospitalised.

How long is immunity to COVID-19 likely to last? The best estimate comes from the closely related coronaviruses and suggests that, in people who had an antibody response, immunity might wane, but is detectable beyond 1 year after hospitalisation.10, 11, 12 Obviously, longitudinal studies with a duration of just over 1 year are of little reassurance given the possibility that there could be another wave of COVID-19 cases in 3 or 4 years. Specific T-lymphocyte immunity against Middle East respiratory syndrome coronavirus, however, can be detectable for 4 years, considerably longer than antibody responses.13

Some of the uncertainty about COVID-19 protective immunity could be addressed by monitoring the frequency of reinfection with SARS-CoV-2. Anecdotal reports of reinfection from China and South Korea should be regarded with caution because some individuals who seemed to have cleared SARS-CoV-2 infection and tested negative on PCR might nevertheless have harboured persistent virus. Virus sequencing studies will help to resolve this issue and in cases of confirmed reinfection it will be important to understand if reinfection correlates with lower immunity.

Policy briefings in the UK and other countries have rightly emphasised the imperative to collect seroprevalence data.14 This approach has sometimes been construed in a narrow sense as testing that would allow people back to work. However, seroprevalence data can show what proportion of a population has been exposed to and is potentially immune to the virus, and is thus wholly distinct from the snapshot of people who accessed PCR testing. How can one determine how much herd immunity is sufficient to mitigate subsequent substantial outbreaks of COVID-19? This calculation depends on several variables,15 including the calculated basic reproduction number (R0), currently believed to be about 2·2 for SARS-CoV-2.16 On the basis of this estimated R0, the herd immunity calculation suggests that at least 60% of the population would need to have protective immunity, either from natural infection or vaccination.17 This percentage increases if R0 has been underestimated.

Most of the available COVID-19 serology data derive from people who have been hospitalised with severe infection.8, 18 In this group, around 90% develop IgG antibodies within the first 2 weeks of symptomatic infection and this appearance coincides with disappearance of virus,18 supporting a causal relationship between these events. However, a key question concerns antibodies in non-hospitalised individuals who either have milder disease or no symptoms. Anecdotal results from community samples yield estimates of under 10% of tested “controls” developing specific IgG antibodies. We await larger seroprevalence datasets, but it seems likely that natural exposure during this pandemic might, in the short to medium term, not deliver the required level of herd immunity and there will be a substantial need for mass vaccination programmes.

There are more than 100 candidate COVID-19 vaccines in development, with a handful in, or soon to be in, phase 1 trials to assess safety and immunogenicity.4 Candidate vaccines encompass diverse platforms that differ in the potency with which immunity is stimulated, the specific arsenal of immune mediators mobilised, the number of required boosts, durability of protection, and tractability of production and supply chains.3, 4 Safety evaluation of candidate COVID-19 vaccines will need to be of the highest rigour. Some features of the immune response induced by infection, such as high concentrations of tumour necrosis factor and interleukin 6, which could be elicited by some candidate vaccines, have been identified as biomarkers of severe outcome.19

Researchers should be commended for decades of iterative efforts, bringing us to a point where there are many candidate vaccines in development against a novel virus first sequenced in January, 2020. Delivery of efficacious vaccines is not a competitive race to the finish, but a considered evaluation of a safe, potent, global response.4 Few would disagree that science should guide the clinical therapeutic approach to an infected person. Science must also guide policy decisions. Reliance on comprehensive seroprevalence data and a solid, research-based grasp of correlates of protection will allow policy to be guided by secure, evidence-based assumptions on herd immunity, rather than optimistic guesses.

 

[jalimon]

it's not a bad flu. it's far worse

stop trolling

Cannot agree more. We are starting to know a bit more about this virus.

On the positive side:
- many many more could have been already infected without any symptoms
- so death rate could be quite low, no much more then flu

On the negative side:
- we do no know if immunity exists
- we still currently have no treatment, vaccines or massive rapid testing capabilities
- case of stroke due to blood clot have doubled (leading to many avc or other related blood clot problem). Which may explain why only 11% of patient survive the ventilator. Blood clot can lead to many other problems.
- the NHS in the UK discovered that covind-19 is probably responsible for a very rare disease for kids
- Impaired lung from covid-19 can very well lead to many other effects on your brain, kidney and your heart. Not to mentions of course.. your lungs.

For the next few months I will let the yahoo's get back to regular partying life and myself remain quiet.

Cheers,

 

[bignasty]

June? Are you fucking kidding me??? There's not a chance in hell that the border opens up in 2020 and if our government succumbs to the pressure and re-opens it too soon than I'M NOT VOTING LIBERAL AGAIN FOR THE REST OF MY LIFE!!!

Hey Naughty by Nature - You so funny!! I think Doc was the one calling for a a shutdown of Canada, at least from the U.S. for all of 2020.

 

[Doc Holliday]

The United States is such a fucking mess right now that i'd personally advocate that Canada keep its border closed to it for at least one more year. And if fucking Trump is re-elected in November then keep the fucking border closed until 2025! There's no fucking way that they'll get out of this mess if they re-elect this motherfucker!

What Canada needs is a big Wall to keep Americans out. Like the Great Wall of China! And they could build that wall with several beautiful doors to let in people once the lockdown is over. Every province would be allowed a maximum amount of doors & they'd be monitored 24/7 to prevent people from illegally coming in. The Wall would have to be at least 100 feet high & be monitored 24/7 with high tech technology. Robots could be used to patrol the wall....robots equiped with infrared technology.

I love Americans. I love America. I usually would welcome their presence in Canada since they're usually great for the economy & the tourism industry. But we can't risk letting in anyone who would potentially infect or re-infect innocent Canadians with COVID-19. They're the ones who elected this madman as their so-called "leader", so they're to blame for this mess!

"Mr. Trump, build that Wall!!!" (and we'll even force America to pay for it)

On other idea would be to build a country-wide canal from the Maritimes to British Columbia in order to make an island out of Canada. A country that is an island could be better protected from an infected neighbouring country. Could this country-wide canal be built within 5 years? Probably not. But i think it'd be a good idea not just for now, but for the future!

 

[Doc Holliday]

In other news, my upcoming flight to Montreal scheduled for the end of June was cancelled yesterday by my airline company. Among the reasons stated was that it seems unlikely that the province of Quebec will by then be re-opened to visitors from visiting provinces or other countries. I was thinking of maybe going by car but now it appears i won't even be allowed inside the province. Oh well!!!

Also yesterday i learned that the Quebec government is warning its residents that if they decide to venture into Ontario then they'll have to go into a 2-week quarantine once they return to Quebec. Most of the Quebec residents i spoke to about this are enraged about this if their government makes this official. I'm hearing it is or the announcement is imminent.

 

[cloudsurf]

In some possible good news......Oxford scientists say that they may have a vaccine ready by September if it works as well on humans as it does on rhesus monkeys.
The New York Times reports that a similar vaccine for another virus was developed a year ago and was proven safe to humans. The new vax was tested on monkeys who then received a strong dose of novel corona virus and did not develop covid19.....while similar tests with a placebo caused infection.
This vax may be available to the masses before year end. I hope it works .

 

[2fast2slow]

and this company already started producing 40 M doses they are so confident it will work

https://www.businessinsider.com/ind...ord-university-vaccine-before-approval-2020-4

 

[jalimon]

To follow up my last post regarding the unknown of this virus came yesterday (sorry it's in french):
https://www.ledevoir.com/societe/sante/577785/la-face-cachee-de-la-maladie

Seems like this virus had a few unknown tricks that makes it a "perfect" virus...